New Cell Manufacturing Research Facility will Change Approaches to Disease Therapies
By John Toon – The vision of making affordable, high-quality cell-based therapies available to hundreds of thousands of patients worldwide moved closer to reality June 6 with the dedication of a new cell manufacturing research facility at Georgia Tech aimed at changing the way we think about medical therapies.
The new Good Manufacturing Practice (GMP) like ISO 8 and ISO 7 compliant facility is part of the existing Marcus Center for Therapeutic Cell Characterization and Manufacturing (MC3M). The center was established in 2016 and made possible by a $15.75 million gift from philanthropist Bernie Marcus, with a $7.25 million investment from Georgia Tech and another $1 million from the Georgia Research Alliance.
MC3M is already helping researchers from Georgia Tech and partner organizations develop ways to provide therapeutic living cells of consistent quality in quantities large enough to meet the growing demands for the cutting-edge treatments. more>
- Sodium- and Potassium-based Batteries Hold Promise for Cheap Energy Storage, Josh Brown
- Georgia Tech Team Receives DARPA Grant to Apply Neuroscience to Machine Learning, Niccole Coleman
- Research Charts the Way to More Reliable Carbon-based Microelectronics, Josh Brown
- Making the Oxygen We Breathe, a Photosynthesis Mechanism Exposed, Ben Brumfield
- Aircraft Microbiome Much Like That of Homes and Offices, Study Finds, John Toon
- I Saw That. Brain Mechanisms Create Confidence About Things Seen, Ben Brumfield
- Spooky Quantum Particle Pairs Fly Like Weird Curveballs, Ben Brumfield
- In Child-Crippling Mucolipidosis IV, Drug Shows Hope in Lab Cultures, Ben Brumfield
- New Frontiers Beckon Math and Biology in Multimillion Dollar NSF-Simons Project, Ben Brumfield
- Shining a Light on Toxic Chemicals Curbs Industrial Use, Josh Brown
- Study Shows How Bacteria Behave Differently in Humans Compared to the Lab, John Toon
- Letting the Cat Out of the Bag: Why Researchers Disclose Results Ahead of Publication, Josh Brown
- Delving into the Perchlorate Diners of Pilot Valley, Utah, A. Maureen Rouhi
- Bacterial Conversations in Cystic Fibrosis, A. Maureen Rouhi
Posted in Business, Economic development, Education, Healthcare, Nature, Science, Technology
Tagged Biology, Business improvement, Electronics, Georgia Tech, Health, Manufacturing, Physics, Technology
Consolidating 3D Printing Tool Chains to Mitigate Risk in Medical Device Applications
By J Thompson – Use of 3D Printing technology to create medical devices has been widely publicized over the past several years. Most of these stories illustrate the unique ability for 3D Printing (aka Additive Manufacturing / AM) technology to produce highly complex organic shapes.
Despite past success with AM, and very promising growth opportunities, there are significant risks with the current AM practices for workflows in device design and manufacturing. These risks must be recognized and addressed by device makers to fully realize the potential of AM, and avoid failure modes inherent in current practices.
Today, the biggest risks are caused by software “tool chains” in which different, specialized software applications are used sequentially to yield finished devices. A fundamental problem with serial tool chains is rework. What happens when you get off the “happy path”, and issues are discovered in the fourth, fifth, or tenth tool in the chain, and resolution requires a change in the first or second tool in the chain? That typically means serially reworking the entire workflow from the point of change.
This kind of rework should be viewed as expected, normal, necessary, commonplace, and even desirable since it theoretically leads to an improved final result. However, as AM attempts to enter an “industrial” stage of maturity, there are several risks associated a serial tool chain, especially if rework is manual and requires experts to re-do knowledge-intensive rework. more>
Posted in Business, Economic development, Education, Healthcare, Nature, Product, Science, Technology
Tagged 3D printing, Additive manufacturing, Business improvement, Health, Manufacturing, Productivity, Siemens, Technology
5 ways to future-proof your network today to support IoT tomorrow
By Rob Tomkins – There is no getting around the fact that networks are seeing an explosion of data coming from “smart” objects that connect the physical and digital worlds. In fact, IHS forecasts that the market will grow from 15.4 billion devices in 2015 to 75.4 billion in 2025. Despite this increase in data, and no matter what new IoT technology or application is announced, users’ expectations remain high — networks must be up and running constantly and bandwidth must always available.
Plus, now that IoT, including Industrial IoT, is becoming more intertwined with mission-critical services such as smart grids and emergency alert systems — the stakes are even higher. Even the slightest network latency or jitter goes beyond a simple inconvenience and has the potential to cause life-threatening situations.
The time is now for service providers, enterprises and cities to get their networks in shape to handle the increase in bandwidth requirements, as well as prepare for what is to come tomorrow. Unfortunately, while it’s a simple concept, it’s not such a simple task.
In many ways, the current IoT landscape resembles the Wild West. more>
Posted in Broadband, Communication industry, Economy, Net, Technology
Tagged 400G, Broadband, Ciena, Health, Internet, IoT, Net evolution, Technology
Simulation Supports Program to Help Pilots in Degraded Visual Environments
By John Toon – A degraded visual environment occurs when helicopters landing on loose soil, such as desert terrain, stir up dust that creates brownout conditions which make it challenging for pilots to see obstacles on the ground. The simulation will support the development of a multi-sensor system designed to give U.S. Army rotorcraft pilots better situational awareness during these challenging conditions.
GTRI researchers are developing different ways to show fused sensor images to pilots during brownout conditions. In an Army cockpit simulator lab, experienced rotorcraft pilots will use the simulations to determine how information should be presented during high-stress approach, landing and takeoff conditions. The pilot feedback will assist the Army in defining the Pilot Vehicle Interface for the new Degraded Visual Environment (DVE) system that will be used on Black Hawk and Chinook helicopters. It will also be used to inform a milestone decision for integration into the Army aviation platforms.
The simulation project is challenging because the data comes from different sources, at different data rates and different resolutions. The emulator must work accurately under varying conditions, including daytime and nighttime operations. Because the system is used to analyze pilot interaction with the new sensors, the provided solution includes flexibility to easily reconfigure various parameters such as symbology sets, types of sensors, sensor performance characteristics, and symbology color. more>
- Researchers Determine Routes of Respiratory Infectious Disease Transmission on Aircraft, John Toon
- A Future Colorfully Lit by the Mystifying Physics of Paint-On Semiconductors, Ben Brumfield
- Turbocharging Fuel Cells with a Multifunctional Catalyst, Ben Brumfield
- The Minds of the New Machines, T.J. Becker
- Modernizing Information Systems to Support a New Generation of Army Families, Josh Brown
- New Insights Could Pave The Way For Self-Powered Low Energy Devices, Josh Brown
- Easy as 1, 2, 3! Really? A. Maureen Rouhi
- Comparison Shows Value of DNA Barcoding in Selecting Nanoparticles, John Toon
- More Startups Join Engage, Laura Diamond
- Deep Learning Can Now Help Prevent Heart Failure, Kristen Perez
- The Next Frontier in Molecular Engineering, Georgia Parmelee
- Georgia Tech Researchers Bring Transparency to Telephone Blacklists, Tess Malone
Posted in Broadband, Business, Energy & emissions, Net, Science, Technology, Transportation
Tagged Broadband, Business improvement, Georgia Tech, Health, Nature, Technology
Industrial Medicine: Cell Therapy Scales Up
By Maggie Sieger – Cell therapy is a new way to treat serious diseases like cancer by extracting living cells from a donor or a patient, changing them so they can recognize and attack diseased cells or deliver treatment, and returning them to the patient’s body. But manufacturing the cells is a costly and time-consuming endeavor. A single dose can cost hundreds of thousands of dollars to make.
That’s because in the more than 900 ongoing regenerative medicine trials worldwide — a 19 percent jump since 2016 — researchers generally manufacture each patient’s dose of bio-engineered cells by hand. The individualized nature of cell therapy makes it not only prohibitively pricey, but also difficult to scale into commercial production.
That hasn’t been a problem while cell therapy was still confined to research labs. But as medical science advances and regulators approve a growing numbers of modified cell therapies for general use, handcrafting doses won’t be enough. “It’s relatively easy to do 15 or 20 doses by hand, but it’s nearly impossible to efficiently make thousands,” says GE Healthcare’s Aaron Dulgar-Tulloch, director of cell therapy research and development at the Centre for Advanced Therapeutic Cell Technologies (CATCT) in Toronto.
One way to speed the process is GE Healthcare’s FlexFactory for cell therapy. Cellular Biomedicine Group Inc. (CBMG) will be the first company to install this closed, semi-automated system for manufacturing bio-engineered cells in its Shanghai plant and use it to create cell therapies to treat various blood and solid tumor cancers. more>
Posted in Business, Economic development, Economy, Education, Healthcare, Nature, Science, Technology
Tagged Business improvement, Cancer, Cell therapy, GE, Health, Manufacturing
Robot Monitors Chicken Houses and Retrieves Eggs
By John Toon – “Today’s challenge is to teach a robot how to move in environments that have dynamic, unpredictable obstacles, such as chickens,” said Colin Usher, a research scientist in GTRI’s Food Processing Technology Division.
“When busy farmers must spend time in chicken houses, they are losing money and opportunities elsewhere on the farm. In addition, there is a labor shortage when it comes to finding workers to carry out manual tasks such as picking up floor eggs and simply monitoring the flocks. If a robot could successfully operate autonomously in a chicken house 24 hours a day and seven days a week, it could then pick up floor eggs, monitor machinery, and check on birds, among other things. By assigning one robot to each chicken house, we could also greatly reduce the potential for introductions of disease or cross-contamination from one house to other houses.”
The autonomous robot is outfitted with an ultrasonic localization system similar to GPS but more suited to an indoor environment where GPS might not be available. This system uses low-cost, ultrasonic beacons indicating the robot’s orientation and its location in a chicken house. The robot also carries a commercially available time-of-flight camera, which provides three-dimensional (3D) depth data by emitting light signals and then measuring how long they take to return. The localization and 3D data together allow the robot’s software to devise navigation plans around chickens to perform tasks. more>
- Real-Time Captcha Technique Improves Biometric Authentication, John Toon
- Data Detectives Shift Suspicions in Alzheimer’s from Usual Suspect to Inside Villain, Ben Brumfield
- Why Bees Soared and Slime Flopped as Inspirations for Systems Engineering, Ben Brumfield
- Asteroid “Time Capsules” May Help Explain How Life Started on Earth, John Toon
- Georgia Tech Trio Selected to National Academy of Engineering, Jason Maderer/Kay Kinard
- Successful SpaceX Launch Clears Way for Historic Georgia Tech Spacecraft, Jason Maderer
- Hatchet Enzyme, Enabler of Sickness and of Health, Exposed by Neutron Beams, Ben Brumfield
- Neurons Get the Beat and Keep It Going in Drumrolls, Ben Brumfield
- Yeast Assay Helps Reveal Genesis of Amyloids and Prions, A. Maureen Rouhi
- Self-assembled “Hairy” Nanoparticles Could Give a Double Punch to Cancer, John Toon
- Manufacturing Disaster Assistance Program to help Georgia companies prepare for natural disasters, Ben Cheeks
- Disclosing Weaknesses Can Undermine Some Workplace Relationships, Josh Brown
- Maelstroms in the Heart Confirmed
- The Next Frontier in Mechanical Engineering, Georgia Parmelee
- Air Force Grant Enables Quantum Simulation Using Cold Atoms, A. Maureen Rouhi
Posted in EARTH WATCH, Education, Energy & emissions, Healthcare, Nature, Net, Science, SPACE WATCH, Technology
Tagged Broadband, Business improvement, Climate change, Earth, Health, Industrial economy, Physics, Productivity, Technology
Brain-computer interfaces may change what it means to be human
Economist – Both America’s armed forces and Silicon Valley are starting to focus on the brain. Facebook dreams of thought-to-text typing. Kernel, a startup, has $100m to spend on neurotechnology. Elon Musk has formed a firm called Neuralink; he thinks that, if humanity is to survive the advent of artificial intelligence, it needs an upgrade. Entrepreneurs envisage a world in which people can communicate telepathically, with each other and with machines, or acquire superhuman abilities, such as hearing at very high frequencies.
These powers, if they ever materializes, are decades away. But well before then, BCIs (brain-computer interfaces) could open the door to remarkable new applications.
Over 300,000 people have cochlear implants, which help them to hear by converting sound into electrical signals and sending them into the brain. Scientists have “injected” data into monkeys’ heads, instructing them to perform actions via electrical pulses.
Technology changes the way people live. Beneath the skull lies the next frontier. more>
Posted in Broadband, Economy, Healthcare, Media, Nature, Net, Science, Technology
Tagged brain-computer interfaces, Business improvement, Electronics, Health, Technology
Leisure, the Basis of Culture, Author: Josef Pieper.
An Obscure German Philosopher’s Timely 1948 Manifesto for Reclaiming Our Human Dignity in a Culture of Workaholism
By Maria Popova – Today, in our culture of productivity-fetishism, we have succumbed to the tyrannical notion of “work/life balance” and have come to see the very notion of “leisure” not as essential to the human spirit but as self-indulgent luxury reserved for the privileged or deplorable idleness reserved for the lazy. And yet the most significant human achievements between Aristotle’s time and our own — our greatest art, the most enduring ideas of philosophy, the spark for every technological breakthrough — originated in leisure, in moments of unburdened contemplation, of absolute presence with the universe within one’s own mind and absolute attentiveness to life without, be it Galileo inventing modern timekeeping after watching a pendulum swing in a cathedral or Oliver Sacks illuminating music’s incredible effects on the mind while hiking in a Norwegian fjord.
So how did we end up so conflicted about cultivating a culture of leisure? more>
Posted in Book review, Broadband, Business, Economy, Healthcare, History, Leadership, Media, Net, Technology
Tagged Business, Health, Internet, Jobs, Leisure, Technology, Workaholism